Publications

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Journal Articles

Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer Permalink

Published in Nature Communications, 2025

This paper presents the conclusions of our extensive benchmark of multimodal machine learning approaches to predict immunotherapy outcome in non-small cell lung cancer (NSCLC). This analysis was performed on an original cohort of metastatic NSCLC patients treated with first line immunotherapy, gathering data modalities such as Positron Emission Tomography scans, bulk RNA transcriptomic data from biopsy tissues, or pathological slides.

Recommended citation: Captier, N., Lerousseau, M., Orlhac, F. et al. Integration of clinical, pathological, radiological, and transcriptomic data improves prediction for first-line immunotherapy outcome in metastatic non-small cell lung cancer. Nat Commun 16, 614 (2025).

RadShap: An Explanation Tool for Highlighting the Contributions of Multiple Regions of Interest to the Prediction of Radiomic Models Permalink

Published in Journal of Nuclear Medicine, 2024

This paper presents RadShap, a model- and modality-agnostic tool, based on Shapley values, that explains the predictions of multiregion radiomic models by highlighting the contribution of each individual region.

Recommended citation: Captier N, Orlhac F, Hovhannisyan-Baghdasarian N, Luporsi M, Girard N, Buvat I. RadShap: An Explanation Tool for Highlighting the Contributions of Multiple Regions of Interest to the Prediction of Radiomic Models. J Nucl Med. 2024.

Promising Candidate Prognostic Biomarkers in [18F]FDG PET Images: Evaluation in Independent Cohorts of Non–Small Cell Lung Cancer Patients Permalink

Published in Journal of Nuclear Medicine, 2024

This paper presents an independent evaluation of two new imaging biomarkers for Positron Emission Tomography (PET), related to the distance between the tumor hotspot of the radiotracer uptake and its centroid or surface.

Recommended citation: Hovhannisyan-Baghdasarian N, Luporsi M, Captier N, Nioche C, Cuplov V, Woff E, Hegarat N, Livartowski A, Girard N, Buvat I, Orlhac F. Promising Candidate Prognostic Biomarkers in [18F]FDG PET Images: Evaluation in Independent Cohorts of Non-Small Cell Lung Cancer Patients. J Nucl Med. 2024.

BIODICA: a computational environment for Independent Component Analysis of omics data Permalink

Published in Bioinformatics, 2022

This paper presents BIODICA, a computational environment for the application of Independent Component Anlysis to omics data.

Recommended citation: Captier N, Merlevede J, Molkenov A, Seisenova A, Zhubanchaliyev A, Nazarov PV, Barillot E, Kairov U, Zinovyev A. BIODICA: a computational environment for Independent Component Analysis of omics data. Bioinformatics. 2022.

Preprints & Under submission

Similar performance of 8 machine learning models on 71 censored medical datasets: a case for simplicity Permalink

2024

This paper presents the conclusions of an extensive benchmark of machine learning pipelines (i.e, learning algorithm, feature selection strategy, hyperparameter tuning) to predict survival outcomes in medical datasets.

Recommended citation: Rebaud L, Capobianco N, Captier N, Escobar T, Spottiswoode B, Buvat I. Similar performance of 8 machine learning models on 71 censored medical datasets: a case for simplicity. medRxiv. 2024.

Nicolas Captier